PYR-41

Term ID

CHEBI:192973

Synonyms

4-[4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl]-benzoic acid ethyl ester
ethyl 4-{4-[(5-nitrofuran-2-yl)methylidene]-3,5-dioxopyrazolidin-1-yl}benzoate
PYR 41
PYR41
UBEI-41

Definition

An ethyl ester resulting from the formal condensation of the carboxy group of 4-{4-[(5-nitrofuran-2-yl)methylidene]-3,5-dioxopyrazolidin-1-yl}benzoic acid with ethanol. It is an irreversible and cell-permeable inhibitor of ubiquitin-activating enzyme E1.

References

cas:418805-02-4
hmdb:HMDB0256938
pubmed:17909057
pubmed:21621524
pubmed:21950462
pubmed:23333241
pubmed:24456201
pubmed:25138535
pubmed:25527164
pubmed:25980497
pubmed:26919560
pubmed:28535513
pubmed:28661933
pubmed:28963785
pubmed:29355596
pubmed:29771572
pubmed:30069488
pubmed:30249396
pubmed:30257893
pubmed:30383222
pubmed:32184710
pubmed:32258175
pubmed:32293245
pubmed:32298286
pubmed:32683298
pubmed:32912211
pubmed:33129231
pubmed:33291814
pubmed:33591981
wikipedia.en:PYR-41

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from PYR-41

Phenotype where environments contain PYR-41

Phenotype modified by environments containing PYR-41

Phenotype affecting PYR-41

Human Disease Model