SM-164

Term ID

CHEBI:192710

Synonyms

• (3S,6S,10aS)-6-{[(2S)-2-(methylamino)propanoyl]amino}-N-[(S)-(1-{4-[4-(4-{4-[(S)-({[(3S,6S,10aS)-6-{[(2S)-2-(methylamino)propanoyl]amino}-5-oxodecahydropyrrolo[1,2-a]azocin-3-yl]carbonyl}amino)(phenyl)methyl]-1H-1,2,3-triazol-1-yl}butyl)phenyl]butyl}-1H-1
• SM 164
• SM164

Definition

A potent cell-permeable and bivalent Smac mimetic which binds to XIAP, cIAP-1 and cIAP-2 proteins (Ki = 0.56 nM, 0.31 nM and 1.1 nM, respectively). It induces apoptosis and tumor regression in cancer xenograft models.

References

• cas:957135-43-2
• pubmed:17999504
• pubmed:19010913
• pubmed:21282353
• pubmed:21372226
• pubmed:21462933
• pubmed:21901386
• pubmed:22148838
• pubmed:23142291
• pubmed:23240027
• pubmed:23699656
• pubmed:31059038
• pubmed:32332865
• pubmed:35525732

Ontology

ChEBI  ( EBI )