LY 379268

Term ID

CHEBI:192545

Synonyms

(1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid
LY-379,268
LY-379268
LY379268

Definition

An organic heterobicyclic compound that is (1R,5S)-2-oxabicyclo[3.1.0]hexane carrying amino, carboxy, and carboxy groups at positions 4R, 4R and 6R, respectively. It is a potent agonist of group II metabotropic glutamate receptors mGluR₂ and mGluR₃ (EC₅₀ = 2.69 nM and 4.48 nM, respectively) that exhibits antipsychotic-like action in animal models of schizophrenia.

References

cas:191471-52-0
pubmed:10090786
pubmed:21139059
pubmed:21477044
pubmed:22659409
pubmed:22820300
pubmed:23593498
pubmed:23624743
pubmed:23769742
pubmed:23827202
pubmed:23948211
pubmed:23953655
pubmed:24631484
pubmed:24859609
pubmed:25063582
pubmed:25158962
pubmed:26044619
pubmed:26149611
pubmed:26241341
pubmed:26317098
pubmed:26861891
pubmed:26955838
pubmed:27394931
pubmed:29462112
pubmed:29562588
pubmed:29858599
pubmed:30909243
pubmed:31306647
pubmed:31536785
pubmed:31580222
pubmed:31705165
pubmed:33763176
pubmed:34330748
pubmed:34416343
pubmed:35772967
wikipedia.en:LY-379,268

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from LY 379268

Phenotype where environments contain LY 379268

Phenotype modified by environments containing LY 379268

Phenotype affecting LY 379268

Human Disease Model