Search Ontology:
ChEBI
BAY-826
- Term ID
- CHEBI:192483
- Synonyms
-
- 3-cyano-N-{2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-5-(pentafluoro-lambda(6)-sulfanyl)benzamide
- [3-cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carbonyl]phenyl]pentafluorosulfur
- BAY 826
- BAY826
- Definition
- A secondary carboxamide resulting from the formal condensation of the carboxy group of 3-cyano-5-(pentafluoro-λ6-sulfanyl)benzoic acid with the amino group of 2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]aniline. It is a potent TIE-2 inhibitor (Kd = 1.6 nM) which displays in vivo efficacy in some murine glioma models.
- References
-
- cas:1448316-08-2
- patent:US9394309
- pubmed:27787897
- pubmed:29676732
- pubmed:33673213
- pubmed:34335960
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from BAY-826
Phenotype where environments contain BAY-826
Phenotype modified by environments containing BAY-826
Phenotype affecting BAY-826
Human Disease Model