Search Ontology:
ChEBI
SU11274
- Term ID
- CHEBI:190974
- Synonyms
-
- (3Z)-N-(3-chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl}methylidene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
- PKI-SU11274
- SU 11274
- SU-11274
- Definition
- A member of the class of oxindoles that is 1,3-dihydro-2H-indol-2-one substituted by {3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl}methylidene and N-(3-chlorophenyl)-N-methylmethanesulfonyl groups at positions 3 and 5, respectively. It is a potent ATP-competitive inhibitor of c-Met (IC50 = 20 nM) and exhibits antineoplastic activity.
- References
-
- cas:658084-23-2
- chemspider:7828213
- lincs.smallmolecule:LSM-42792
- pdb-ccd:274
- pubmed:15064724
- pubmed:15735036
- pubmed:18021219
- pubmed:18239682
- pubmed:19238632
- pubmed:19783361
- pubmed:20370683
- pubmed:21572247
- pubmed:21575221
- pubmed:22466960
- pubmed:22673163
- pubmed:23026049
- pubmed:23360489
- pubmed:23527257
- pubmed:23536000
- pubmed:23566349
- pubmed:23876900
- pubmed:25279148
- pubmed:26622692
- pubmed:26790028
- pubmed:27175734
- pubmed:28835699
- pubmed:29752941
- pubmed:30233210
- pubmed:32428505
- pubmed:32686903
- pubmed:33227394
- pubmed:33344167
- pubmed:34257586
- pubmed:35760785
- pubmed:38273381
- pubmed:38442547
- pubmed:38766346
- pubmed:38820210
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from SU11274
Phenotype where environments contain SU11274
Phenotype modified by environments containing SU11274
Phenotype affecting SU11274
Human Disease Model