RepSox

Term ID

CHEBI:190969

Synonyms

2-(3-(6-methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
2-[3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine
ALK5 Inhibitor II
E 616452
E-616452
E616452
SJN 2511
SJN-2511
SJN2511
TGF-beta RI Kinase Inhibitor II

(all 10)

Definition

A member of the class of pyrazoles that is 1H-pyrazole substituted by 6-methylpyridin-2-yl and 1,5-naphthyridin-2-yl groups at positions 3 and 4, respectively. It is a potent and selective inhibitor of TGF-beta R1 kinase (IC50 = 4 nM) and ALK5 autophosphorylation and binding (IC50 = 23 nM).

References

(all 23)

Ontology

ChEBI ( EBI )

Relationships

is a type of: 1,5-naphthyridine derivative pyrazoles pyridines

1,5-naphthyridine derivative pyrazoles pyridines Show first 5 Terms
has_role: antineoplastic agent bone density conservation agent EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor TGFbeta receptor antagonist

antineoplastic agent bone density conservation agent EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor TGFbeta receptor antagonist Show first 5 Terms

Phenotype

Phenotype resulting from RepSox

Phenotype where environments contain RepSox

Phenotype modified by environments containing RepSox

Phenotype affecting RepSox

Human Disease Model