RepSox

Term ID

CHEBI:190969

Synonyms

2-(3-(6-methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
2-[3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine
ALK5 Inhibitor II
E 616452
E-616452
E616452
SJN 2511
SJN-2511
SJN2511
TGF-beta RI Kinase Inhibitor II

Definition

A member of the class of pyrazoles that is 1H-pyrazole substituted by 6-methylpyridin-2-yl and 1,5-naphthyridin-2-yl groups at positions 3 and 4, respectively. It is a potent and selective inhibitor of TGF-β R1 kinase (IC₅₀ = 4 nM) and ALK5 autophosphorylation and binding (IC₅₀ = 23 nM).

References

agr:IND605727048
cas:446859-33-2
chemspider:395681
hmdb:HMDB0257156
pubmed:19818703
pubmed:24855276
pubmed:28247195
pubmed:28418584
pubmed:29685182
pubmed:30059597
pubmed:31235818
pubmed:31313941
pubmed:31600351
pubmed:34132357
pubmed:34252142
pubmed:34533199
pubmed:35794374
pubmed:36219879
pubmed:37760872
pubmed:37931000
pubmed:38229139
reaxys:9782770
wikipedia.en:RepSox

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from RepSox

Phenotype where environments contain RepSox

Phenotype modified by environments containing RepSox

Phenotype affecting RepSox

Human Disease Model