Search Ontology:
ChEBI
DDR1-IN-1
- Term ID
- CHEBI:189867
- Synonyms
-
- 4-((4-ethylpiperazin-1-yl)methyl)-N-(4-methyl-3-(2-oxoindolin-5-yloxy)phenyl)-3-(trifluoromethyl)benzamide
- 4-[(4-ethylpiperazin-1-yl)methyl]-N-{4-methyl-3-[(2-oxo-2,3-dihydro-1H-indol-5-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide
- N-[3-[(2,3-dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide
- Definition
- A secondary carboxamide resulting from the formal condensation of the carboxy group of 4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzoic acid with the amino group of 5-(5-amino-2-methylphenoxy)-1,3-dihydro-2H-indol-2-one. It is a potent inhibitor of discoidin domain receptor tyrosine kinase 1 and 2 (DDR1/2) with IC50 = 105 nM and 413 nM, respectively.
- References
-
- CAS:1449685-96-4
- Chemspider:32490190
- PDBeChem:DI1
- PMID:23899692
- PMID:24768818
- PMID:25569119
- PMID:29170554
- PMID:30783426
- PMID:31271515
- PMID:33110221
- Ontology
- ChEBI ( EBI )
- is a type of
- has_role
-
Phenotype
Phenotype resulting from DDR1-IN-1
Phenotype where environments contain DDR1-IN-1
Phenotype modified by environments containing DDR1-IN-1
Human Disease / Model Data