C75

Term ID

CHEBI:189865

Synonyms

• (+-)-C75
• (2R*,3S*)-4-methylidene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
• (2R*,3S*)-tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic acid
• C75 (racemic mixture of trans-isomers)
• C75 trans
• rac-(2R,3S)-4-methylidene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
• trans-C 75
• trans-C75
• trans-tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic acid

Definition

A racemate comprising equimolar amount of (2R,3S)-C75 and its enantiomer, (2S,3R)-C75. It is a fatty-acid synthase (FAS) inhibitor and an activator of carnitine palmitoyl-transferase-1 that leads to weight loss and feeding inhibition in mice.

References

• CAS:191282-48-1
• PMID:12060712
• PMID:12724522
• PMID:14615481
• PMID:15541339
• PMID:15715522
• PMID:16169094
• PMID:16484442
• PMID:16584169
• PMID:18667714
• PMID:18706411
• PMID:19040646
• PMID:19094968
• PMID:20026180
• PMID:22348016
• PMID:22698429
• PMID:22754424
• PMID:22769244
• PMID:23620264
• PMID:23827961
• PMID:24306512
• PMID:24784139
• PMID:26372196
• PMID:27901292
• PMID:33083663
• PMID:34457121
• PMID:35050128
• PMID:35489715

Ontology

ChEBI  ( EBI )