C75

Term ID

CHEBI:189865

Synonyms

(+-)-C75
(2R*,3S*)-4-methylidene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
(2R*,3S*)-tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic acid
C75 (racemic mixture of trans-isomers)
C75 trans
rac-(2R,3S)-4-methylidene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
trans-C 75
trans-C75
trans-tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic acid

Definition

A racemate comprising equimolar amount of (2R,3S)-C75 and its enantiomer, (2S,3R)-C75. It is a fatty-acid synthase (FAS) inhibitor and an activator of carnitine palmitoyl-transferase-1 that leads to weight loss and feeding inhibition in mice.

References

cas:191282-48-1
pubmed:12060712
pubmed:12724522
pubmed:14615481
pubmed:15541339
pubmed:15715522
pubmed:16169094
pubmed:16484442
pubmed:16584169
pubmed:18667714
pubmed:18706411
pubmed:19040646
pubmed:19094968
pubmed:20026180
pubmed:22348016
pubmed:22698429
pubmed:22754424
pubmed:22769244
pubmed:23620264
pubmed:23827961
pubmed:24306512
pubmed:24784139
pubmed:26372196
pubmed:27901292
pubmed:33083663
pubmed:34457121
pubmed:35050128
pubmed:35489715

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from C75

Phenotype where environments contain C75

Phenotype modified by environments containing C75

Phenotype affecting C75

Human Disease Model