palovarotene

Term ID

CHEBI:188559

Synonyms

• 4-{(E)-2-[5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-5,6,7,8-tetrahydronaphthalen-2-yl]ethenyl}benzoic acid
• CLM 001
• CLM-001
• palovarotene
• palovaroteno
• palovarotenum
• R-667
• R667
• RG-667
• RO 3300074
• RO-3300074
• RO3300074
• Sohonos

Definition

An olefinic compound that is ethene is which a hydrogen at position 1 is replaced by a 4-carboxyphenyl group and a hydrogen at position 2 is replaced by a 5,5,8,8-tetramethyl-3-[(1H-pyrazol-1-yl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl group (the E-stereoisomer). It is a selective retinoic acid receptor γ (RARγ) agonist developed by Ipsen, to reduce the formation of new heterotopic ossification in adults and children with fibrodysplasia ossificans progressiva (FOP), a rare bone disorder.

References

• cas:410528-02-8
• chemspider:8470763
• drugbank:DB05467
• kegg.drug:D09365
• lincs.smallmolecule:LSM-45512
• pmc:PMC7208379
• pmc:PMC9624757
• pubmed:17324249
• pubmed:19876792
• pubmed:26896819
• pubmed:28960501
• pubmed:29120519
• pubmed:30226468
• pubmed:30698142
• pubmed:32245464
• pubmed:34383202
• pubmed:34831466
• pubmed:35384641
• pubmed:35530413
• pubmed:35638441
• pubmed:35646981
• pubmed:35802768
• pubmed:35854638
• pubmed:36052494
• pubmed:36542308
• pubmed:36583535
• pubmed:36802022
• pubmed:37643264
• pubmed:37796111
• pubmed:37804430
• pubmed:37934835
• pubmed:37957586
• pubmed:38130748
• wikipedia.en:Palovarotene

Ontology

ChEBI  ( EBI )