Search Ontology:
ChEBI

palovarotene

Term ID
CHEBI:188559
Synonyms
  • 4-{(E)-2-[5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-5,6,7,8-tetrahydronaphthalen-2-yl]ethenyl}benzoic acid
  • CLM 001
  • CLM-001
  • palovarotene
  • palovaroteno
  • palovarotenum
  • R-667
  • R667
  • RG-667
  • RO 3300074
  • RO-3300074
  • RO3300074
  • Sohonos
Definition
An olefinic compound that is ethene is which a hydrogen at position 1 is replaced by a 4-carboxyphenyl group and a hydrogen at position 2 is replaced by a 5,5,8,8-tetramethyl-3-[(1H-pyrazol-1-yl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl group (the E-stereoisomer). It is a selective retinoic acid receptor gamma (RARgamma) agonist developed by Ipsen, to reduce the formation of new heterotopic ossification in adults and children with fibrodysplasia ossificans progressiva (FOP), a rare bone disorder.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from palovarotene
Phenotype where environments contain palovarotene
Phenotype modified by environments containing palovarotene
Human Disease Model
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