2,8-dihydroxyadenine

Term ID

CHEBI:183641

Synonyms

2,8-DHA
6-amino-2,8-dihydroxypurine
6-amino-9H-purine-2,8-diol
6-amino-purine-2,8-diol

Definition

A member of the class of 6-aminopurines that is adenine bearing two hydroxy substituents at positions 2 and 8. It is a highly insoluble metabolite of adenine that causes radiolucent urolithiasis. It is produced by individuals who suffer from adenine phosphoribosyltransferase (APRT) deficiency, a rare autosomal recessive error of purine metabolism.

References

cas:30377-37-8
foodb.food:FDB022018
hmdb:HMDB0000401
pubmed:10481956
pubmed:15025810
pubmed:16713382
pubmed:20098761
pubmed:21553389
pubmed:23113528
pubmed:24359665
pubmed:24940675
pubmed:25307253
pubmed:26278213
pubmed:27447713
pubmed:27770717
pubmed:28466077
pubmed:28566603
pubmed:28717278
pubmed:29657221
pubmed:29861153
pubmed:30355577
pubmed:31378568
pubmed:31880754
pubmed:32086278
pubmed:32260098
pubmed:32399606
pubmed:32859011
pubmed:33273797
pubmed:33678741
pubmed:34044400
pubmed:34341261
pubmed:34610707
wikipedia.en:2,8-Dihydroxyadenine

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from 2,8-dihydroxyadenine

Phenotype where environments contain 2,8-dihydroxyadenine

Phenotype modified by environments containing 2,8-dihydroxyadenine

Phenotype affecting 2,8-dihydroxyadenine

Human Disease Model