3,3',5-triiodo-L-thyronine

Term ID

CHEBI:18258

Synonyms

3,3',5-triiodo-L-thyronine
3,5,3'-Triiodo-L-thyronine
3,5,3'-Triiodothyronine
3,5,3'TRIIODOTHYRONINE
4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-L-phenylalanine
L-3,3',5-triiodothyronine
L-3,5,3'-Triiodothyronine
L-T3
L-triiodothyronine
liothyronine
liothyroninum
liotironina
O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine
T3
Tertroxin
Tresitope
Triiodothyronine

Definition

An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.

References

cas:6893-02-3
drugbank:DB00279
drugcentral:1585
hmdb:HMDB0000265
kegg.compound:C02465
kegg.drug:D08128
lincs.smallmolecule:LSM-3991
pdb-ccd:T3
pubmed:11738632
pubmed:15206581
pubmed:19339791
reaxys:2710227
wikipedia.en:Triiodothyronine

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from 3,3',5-triiodo-L-thyronine

Phenotype where environments contain 3,3',5-triiodo-L-thyronine

Phenotype modified by environments containing 3,3',5-triiodo-L-thyronine

Phenotype affecting 3,3',5-triiodo-L-thyronine

Human Disease Model