midafotel

Term ID

CHEBI:180900

Synonyms

• (2R)-4-[(2E)-3-phosphono-2-propenyl]-2-piperazinecarboxylic acid
• (2R)-4-[(2E)-3-phosphonoprop-2-en-1-yl]piperazine-2-carboxylic acid
• (R)-4-[(E)-3-phosphonoprop-2-enyl]piperazine-2-carboxylic acid
• (R)-CPP-ene
• D(-)CPPene
• D-4-[(2E)-3-phosphono-2-propenyl]-2-piperazinecarboxylic acid
• D-CPP-ene
• D-CPPene
• midafotel
• midafotelum
• SDZ EAA 494
• SDZ-EAA 494
• SDZ-EAA-494

Definition

A member of the class of piperazines that is piperazine substituted by a carboxy group at position 2R and a (1E)-1-phosphonoprop-1-en-3-yl group at position 4. It is an antagonist of N-methyl-D-aspartate receptors (NMDARs) and was in clinical development by Novartis for the treatment of cognition disorders and brain injuries (now discontinued).

References

• cas:117414-74-1
• chemspider:4940497
• pubmed:10422758
• pubmed:10708738
• pubmed:11396518
• pubmed:1480321
• pubmed:15497436
• pubmed:1834008
• pubmed:1930876
• pubmed:2147454
• pubmed:2166255
• pubmed:2166743
• pubmed:2292244
• pubmed:31563294
• pubmed:32507787
• pubmed:7675315
• pubmed:7892415
• pubmed:7894335
• pubmed:7936096
• pubmed:7942207
• pubmed:7976650
• pubmed:8194512
• pubmed:8223415
• pubmed:8269915
• pubmed:8581475
• pubmed:8740048
• pubmed:8901001
• pubmed:8982681
• pubmed:9026366
• pubmed:9721021
• pubmed:9726648
• wikipedia.en:Midafotel

Ontology

ChEBI  ( EBI )