N(4)-hydroxycytidine

Term ID

CHEBI:180654

Synonyms

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one
4-N-hydroxycytidine
4-oxime uridine
beta-D-N(4)-hydroxycytidine
EIDD 1931
EIDD-1931
N(4)-hydroxycytidine
N-hydroxy-3,4-dihydrocytidine
N-hydroxycytidine

(all 9)

Definition

A nucleoside analogue that is cytidine which carries a hydroxy group at the N(4)-positon. It has broad-spectrum antiviral activity against influenza, SARS-CoV , SARS-CoV-2 and MERS-CoV.

References

(all 17)

Ontology

ChEBI ( EBI )

Relationships

is a type of: ketoxime nucleoside analogue

ketoxime nucleoside analogue Show first 5 Terms
has_functional_parent: cytidine

cytidine Show first 5 Terms
has_role: anticoronaviral agent antiviral agent drug metabolite human xenobiotic metabolite

anticoronaviral agent antiviral agent drug metabolite human xenobiotic metabolite Show first 5 Terms
inverse has_functional_parent: molnupiravir

molnupiravir Show first 5 Terms

Phenotype

Phenotype resulting from N(4)-hydroxycytidine

Phenotype where environments contain N(4)-hydroxycytidine

Phenotype modified by environments containing N(4)-hydroxycytidine

Phenotype affecting N(4)-hydroxycytidine

Human Disease Model