Search Ontology:
ChEBI
beauveriolide I
- Term ID
- CHEBI:180490
- Synonyms
-
- (3R,6S,9S,13S)-9-benzyl-13-[(2S)-hexan-2-yl]-6-methyl-3-(2-methylpropyl)-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
- Definition
- A cyclodepsipeptide with formula C27H41N3O5. It was originally isolated from the fungus Beauveria sp. FO-6979 during a screening program for inhibitors of lipid droplet accumulation in murine macrophages. It is an inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT) and effective at reducing atherogenic lesions of the artery and heart in mouse models.
- References
-
- cas:154491-55-1
- cba:324779
- chemspider:8088999
- patent:US2003143716
- pubmed:10092189
- pubmed:12617514
- pubmed:14718664
- pubmed:17803269
- pubmed:18620856
- pubmed:19396893
- pubmed:22079027
- pubmed:22790951
- pubmed:23252879
- pubmed:31926180
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from beauveriolide I
Phenotype where environments contain beauveriolide I
Phenotype modified by environments containing beauveriolide I
Phenotype affecting beauveriolide I
Human Disease Model