Search Ontology:
ChEBI

sotorasib

Term ID
CHEBI:178199
Synonyms
  • 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-4-[(2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl]pyrido[2,3-d]pyrimidin-2(1H)-one
  • AMG 510
  • AMG-510
  • AMG510
  • Lumakras
  • sotorasib
  • sotorasibum
Definition
A pyridopyrimidine that is pyrido[2,3-d]pyrimidin-2(1H)-one substituted by 4-methyl-2-(propan-2-yl)pyridin-3-yl, (2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl, fluoro and 2-fluoro-6-hydroxyphenyl groups at positions 1, 4, 6 and 7, respectively. It is approved for the treatment of patients with non-small cell lung cancer having KRASG12C mutations.
References
  • cas:2296729-00-3
  • chemspider:72380148
  • drugbank:DB15569
  • kegg.drug:D12055
  • pubmed:31189530
  • pubmed:31666701
  • pubmed:31820981
  • pubmed:32540954
  • pubmed:32686745
  • pubmed:32955176
  • pubmed:33283304
  • pubmed:33466360
  • pubmed:33547148
  • pubmed:33957355
  • pubmed:33971321
  • pubmed:34004237
  • pubmed:34043291
  • pubmed:34094546
  • pubmed:34096690
  • pubmed:34137282
  • pubmed:34140669
  • pubmed:34144959
  • pubmed:34158284
  • pubmed:34219153
  • pubmed:34301758
  • pubmed:34357500
  • pubmed:34359807
  • wikipedia.en:Sotorasib
Ontology
ChEBI  ( EBI )
Relationships
Phenotype
Phenotype resulting from sotorasib
Phenotype where environments contain sotorasib
Phenotype modified by environments containing sotorasib
Phenotype affecting sotorasib
Human Disease Model