Search Ontology:
ChEBI

plinabulin

Term ID
CHEBI:177413
Synonyms
  • (3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione
  • BPI 2358
  • BPI-2358
  • NPI 2358
  • NPI-2358
  • NPI2358
  • plinabulin
  • plinabulina
  • plinabuline
  • plinabulinum
(all 10)
Definition
A member of the class of 2,5-diketopiperazines that is piperazine-2,5-dione substituted by benzylidene and (5-tert-butyl-1H-imidazol-4-yl)methylidene groups at positions 3 and 6, respectively. It is a vascular disrupting agent and a microtubule destabalising agent which was in clinical trials (now discontinued) for the treatment of non-small cell lung cancer.
References
(all 28)
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from plinabulin
Phenotype where environments contain plinabulin
Phenotype modified by environments containing plinabulin
Phenotype affecting plinabulin
Human Disease Model
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.