brequinar

Term ID

CHEBI:177387

Synonyms

• 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methylquinoline-4-carboxylic acid
• 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid
• 6-fluoro-2-(2'-fluoro[biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid
• 6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid
• 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-quinoline-4-carboxylic acid
• 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid
• biphenquinate
• brequinar
• brequinarum

Definition

A quinolinemonocarboxylic acid that is quinoline substituted by 2'-fluoro[1,1'-biphenyl]-4-yl, methyl, carboxy and fluoro groups at positions 2, 3, 4, and 6, respectively. It is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis. The compound exhibits antineoplastic and antiviral properties.

References

• CAS:96187-53-0
• Chemspider:51422
• DrugBank:DB03523
• LINCS:LSM-45952
• PDBeChem:BRF
• PMID:20606073
• PMID:21840180
• PMID:24013224
• PMID:28833638
• PMID:30663496
• PMID:31146110
• PMID:31557612
• PMID:31635418
• PMID:33007394
• PMID:33080984
• PMID:33344900
• PMID:33437396
• PMID:33584854
• PMID:4053030
• PMID:8132203
• Patent:WO9742953
• Reaxys:8354757
• Wikipedia:Brequinar

Ontology

ChEBI  ( EBI )

Resources

CTD