2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide

Term ID

CHEBI:177298

Synonyms

2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide

Definition

A member of the class of indazoles that is 2H-indazole substituted by 4-(piperidin-3-yl)phenyl and aminocarbonyl groups at positions 2 and 7, respectively. It is a potent PARP1 inhibitor with IC50 of 3.2 nM.

References

PMID:25761096

Ontology

ChEBI ( EBI )

Relationships

is a type of: benzenes indazoles piperidines primary carboxamide

benzenes indazoles piperidines primary carboxamide Show first 5 Terms
has subtype: 2-{4-[(3R)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide niraparib

2-{4-[(3R)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide niraparib Show first 5 Terms
has_role: antineoplastic agent EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor

antineoplastic agent EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide

Phenotype where environments contain 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide

Phenotype modified by environments containing 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide

Human Disease / Model Data

Citations