niraparib

Term ID

CHEBI:176844

Synonyms

2-[4-(3S)-3-piperidinylphenyl]-2H-indazole-7-carboxamide
2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide
2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide
MK 4827
MK-4827
MK4827
niraparib
niraparibum
Zejula

Definition

A 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide that has S-configuration. It is a potent inhibitor of PARP1 and PARP2 (IC₅₀ of 3.8 and 2.1 nM, respectively) and approved as a first-line maintenance treatment for women with advanced ovarian cancer after responding to platinum-based chemotherapy.

References

cas:1038915-60-4
chemspider:24531930
drugbank:DB11793
drugcentral:5222
kegg.drug:D10140
patent:KR20100114021
pdb-ccd:3JD
pubmed:19873981
pubmed:23482742
pubmed:24970803
pubmed:28001384
pubmed:29081841
pubmed:29214031
pubmed:29856239
pubmed:30096696
pubmed:31857852
pubmed:32073931
pubmed:32679152
pubmed:32753559
pubmed:32863940
pubmed:33361107
pubmed:33407715
pubmed:33470063
pubmed:33545804
pubmed:33559417
pubmed:33621324
pubmed:33641880
pubmed:33691564
pubmed:33774805
pubmed:33905671
pubmed:33915252
pubmed:33920140
pubmed:33993885
pubmed:34073147
pubmed:34164503
pubmed:34241562
pubmed:34307148
pubmed:34324028
pubmed:34327724
wikipedia.en:Niraparib

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from niraparib

Phenotype where environments contain niraparib

Phenotype modified by environments containing niraparib

Phenotype affecting niraparib

Human Disease Model