N-nitroso-N-methyl-4-aminobutyric acid

Term ID

CHEBI:176579

Synonyms

4-(methylnitrosamino)butyric acid
4-(methylnitrosoamino)butanoic acid
4-(N-nitroso-N-methylamino)butyric acid
4-[methyl(nitroso)amino]butanoic acid
N-methyl-N-(3-carboxypropyl)nitrosamine
N-nitrosomethyl-3-carboxypropylamine
N-nitrosomethylaminobutyric acid
nitrosomethyl-3-carboxypropylamine
NMBA

Definition

A nitrosamine that has methyl and 3-carboxypropyl substituents. It is a tobacco-derived nitrosamino acid that is a known animal and potential human carcinogen. It induces bladder transitional cell carcinomas in rats and has recently been identified as a contaminant in certain blood pressure medications.

References

cas:61445-55-4
chemspider:39785
pubmed:1017589
pubmed:2718186
pubmed:2766465
pubmed:3131281
pubmed:32613429
pubmed:33426042
pubmed:3978605
pubmed:6355832
pubmed:6398305
pubmed:6573541
pubmed:7141556
pubmed:8131217
pubmed:9489487
reaxys:2245230

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from N-nitroso-N-methyl-4-aminobutyric acid

Phenotype where environments contain N-nitroso-N-methyl-4-aminobutyric acid

Phenotype modified by environments containing N-nitroso-N-methyl-4-aminobutyric acid

Phenotype affecting N-nitroso-N-methyl-4-aminobutyric acid

Human Disease Model