ML162

Term ID

CHEBI:176499

Synonyms

2-chloro-N-(3-chloro-4-methoxyphenyl)-N-{2-oxo-2-[(2-phenylethyl)amino]-1-(thiophen-2-yl)ethyl}acetamide
DPI7
ML 162
ML-162
Molecular Libraries 162

Definition

A monochlorobenzene that is benzene substituted by (chloroacetyl){2-oxo-2-[(2-phenylethyl)amino]-1-(thiophen-2-yl)ethyl}amino, chloro and methoxy groups at positions 1, 3 and 4, respectively. It is a covalent inhibitor of glutathione peroxidase 4 (GPX4) that induces ferroptosis in cells.

References

cas:1035072-16-2
chemspider:2921671
lincs.smallmolecule:LSM-1493
pubmed:22297109
pubmed:22832321
pubmed:27048822
pubmed:30339884
pubmed:33559612

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from ML162

Phenotype where environments contain ML162

Phenotype modified by environments containing ML162

Phenotype affecting ML162

Human Disease Model