FINO2

Term ID

CHEBI:176420

Synonyms

2-[(5s,8s)-8-tert-butyl-3-methyl-1,2-dioxaspiro[4.5]decan-3-yl]ethan-1-ol
2-[(5s,8s)-8-tert-butyl-3-methyl-1,2-dioxaspiro[4.5]decan-3-yl]ethanol

Definition

An oxaspiro compound that is 1,2-dioxaspiro[4.5]decane substituted by methyl, 2-hydroxyethyl and tert-butyl groups at positions 3, 3 and 8, respectivey (the 5s,8s-stereoisomer). It induces ferroptosis in cancer cells by indirectly inhibiting glutathione peroxidase 4 (GPX4) enzymatic function and directly oxidizes iron leading to widespread lipid peroxidation.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: organic heterobicyclic compound organic peroxide oxaspiro compound primary alcohol

organic heterobicyclic compound organic peroxide oxaspiro compound primary alcohol Show first 5 Terms
has_role: antineoplastic agent ferroptosis inducer

antineoplastic agent ferroptosis inducer Show first 5 Terms

Phenotype

Phenotype resulting from FINO2

Phenotype where environments contain FINO2

Phenotype modified by environments containing FINO2

Human Disease / Model Data

Citations