Search Ontology:
ChEBI
GSK2879552
- Term ID
- CHEBI:176334
- Synonyms
-
- 4-{[4-({[(1R,2S)-2-phenylcyclopropyl]amino}methyl)piperidin-1-yl]methyl}benzoic acid
- GSK 2879552
- GSK-2879552
- Definition
- A member of the class of piperidines that is piperidine substituted by (4-carboxyphenyl)methyl and {[(1R,2S)-2-phenylcyclopropyl]amino}methyl groups at positions 1 and 4, respectively. It is a potent and irreversible inhibitor of lysine specific demethylase 1 (LSD1, also known as KDM1A). It was under clinical investigation for the treatment of acute myeloid leukaemia and small cell lung carcinoma.
- References
-
- cas:1401966-69-5
- chemspider:35308350
- patent:WO2012135113
- pubmed:26175415
- pubmed:26710088
- pubmed:27308632
- pubmed:28722477
- pubmed:29972300
- pubmed:30472603
- pubmed:30514804
- pubmed:30713023
- pubmed:31054890
- pubmed:31249575
- pubmed:31260835
- pubmed:31801559
- pubmed:32551003
- pubmed:32850370
- pubmed:32931269
- pubmed:33285227
- pubmed:33708617
- pubmed:33833800
- pubmed:34031383
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from GSK2879552
Phenotype where environments contain GSK2879552
Phenotype modified by environments containing GSK2879552
Phenotype affecting GSK2879552
Human Disease Model