gemcitabine

Term ID

CHEBI:175901

Synonyms

2',2'-Difluorodeoxycytidine
2'-deoxy-2',2'-difluorocytidine
4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
gemcitabina
gemcitabine
gemcitabinum

Definition

A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.

References

beilstein:5382060
cas:95058-81-4
drugbank:DB00441
drugcentral:1283
kegg.compound:C07650
kegg.drug:D02368
lincs.smallmolecule:LSM-5333
patent:EP1939198
patent:EP2108368
patent:EP2275135
patent:GB2136425
patent:US2009124797
patent:US2010111852
patent:US4808614
pdb-ccd:GEO
pubmed:11034044
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pubmed:11088063
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pubmed:19879060
pubmed:22763439
pubmed:28594276
pubmed:28608357
pubmed:28912244
reaxys:5382060
wikipedia.en:Gemcitabine

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from gemcitabine

Phenotype where environments contain gemcitabine

Phenotype modified by environments containing gemcitabine

Phenotype affecting gemcitabine

Human Disease Model