uracil

Term ID

CHEBI:17568

Synonyms

2,4(1H,3H)-pyrimidinedione
2,4-Dioxopyrimidine
2,4-Pyrimidinedione
pyrimidine-2,4(1H,3H)-dione
U
Ura
Uracil
Urazil

Definition

A common and naturally occurring pyrimidine nucleobase in which the pyrimidine ring is substituted with two oxo groups at positions 2 and 4. Found in RNA, it base pairs with adenine and replaces thymine during DNA transcription.

References

CAS:66-22-8
DrugBank:DB03419
Gmelin:2896
HMDB:HMDB0000300
KEGG:C00106
KEGG:D00027
KNApSAcK:C00001513
MetaCyc:URACIL
PDBeChem:URA
PMID:11279060
PMID:12855717
PMID:15274295
PMID:16834123
PMID:17439666
PMID:18533995
PMID:18815805
PMID:19175333
PMID:22020693
PMID:22074393
PMID:22120518
PMID:22171528
PMID:22237209
PMID:22299724
PMID:22356544
PMID:22447672
PMID:22483865
PMID:22567906
PMID:22685418
PMID:3654008
Reaxys:606623
Wikipedia:Uracil

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: pyrimidine nucleobase pyrimidone

pyrimidine nucleobase pyrimidone Show first 5 Terms
has_role: allergen Daphnia magna metabolite Escherichia coli metabolite human metabolite mouse metabolite ... Show All 7 Terms

allergen Daphnia magna metabolite Escherichia coli metabolite human metabolite mouse metabolite prodrug Saccharomyces cerevisiae metabolite Show first 5 Terms
inverse has_functional_parent: (5R)-6-hydroxy-5-[4-(2-hydroxyethyl)piperidin-1-yl]-5-phenyluracil (Z)-2-methylureidoacrylic acid ({[(1R,2R)-2-(uracil-1-yl)cyclopentyl]oxy}methyl)phosphonic acid 1,3-dimethyluracil 1,5-dimethyluracil ... Show All 63 Terms

(5R)-6-hydroxy-5-[4-(2-hydroxyethyl)piperidin-1-yl]-5-phenyluracil (Z)-2-methylureidoacrylic acid ({[(1R,2R)-2-(uracil-1-yl)cyclopentyl]oxy}methyl)phosphonic acid 1,3-dimethyluracil 1,5-dimethyluracil 1-(3-O-phosphono-beta-D-arabinofuranosyl)uracil 1-(ethoxymethyl)-5-isopropyl-6-(phenylsulfanyl)uracil 1-[3-(4-carboxypiperidin-1-yl)-3-deoxy-beta-D-arabinofuranosyl]pyrimidine-2,4(1H,3H)-dione 1-methyluracil 2'-deoxyuridine 3,5-dimethyluracil 3-(5-bromouracil-1-yl)-L-alanine 3-(5-fluorouracil-1-yl)-L-alanine 3-(5-iodouracil-1-yl)-L-alanine 3-(uracil-1-yl)-L-alanine 3-methyluracil 4-[(1E,7E)-8-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-3,6-dioxa-2,7-diazaocta-1,7-dien-1-yl]benzoic acid 4-thiouracil 5,6-dihydrouracil 5,6-dihydroxyuracil 5-(4,5-dihydroxypentyl)uracil 5-[3-(benzyloxy)benzyl]-6-hydroxy-1-[(2-hydroxyethoxy)methyl]pyrimidine-2,4(1H,3H)-dione 5-acetamido-6-formamido-3-methyluracil 5-benzyl-1-(2-hydroxyethoxymethyl)uracil 5-benzyloxybenzylacyclouridine 5-bromouracil 5-carboxy-2'-deoxyuridine 5-chloro-6-{[(2Z)-2-iminopyrrolidin-1-yl]methyl}uracil 5-chlorouracil 5-diazouracil 5-fluorouracil 5-hydroxymethyluracil 5-hydroxyuracil 5-iodouracil 5-nitrouracil 6-(3,5-dimethylbenzyl)-1-(ethoxymethyl)-5-isopropyluracil 6-[(1,2-dideoxy-D-ribityl)amino]-5-[(E)-(2-oxopropylidene)amino]uracil 6-[(1,3-dideoxy-D-ribityl)amino]-5-[(E)-(2-oxopropylidene)amino]uracil 6-[(1,4-dideoxy-D-ribityl)amino]-5-[(E)-(2-oxopropylidene)amino]uracil 6-[(1,5-dideoxy-D-ribityl)amino]-5-[(E)-(2-oxopropylidene)amino]uracil 6-[(1-deoxy-D-ribityl)methyl]-5-[(1E)-3-oxobut-1-en-1-yl]uracil 6-[(2-hydroxyethyl)amino]-5-[(E)-(2-oxopropylidene)amino]uracil 6-[(3-hydroxypropyl)amino]-5-[(E)-(2-oxopropylidene)amino]uracil 6-[(4-hydroxybutyl)amino]-5-[(E)-(2-oxopropylidene)amino]uracil 6-[(5-hydroxypentyl)amino]-5-[(E)-(2-oxopropylidene)amino]uracil 6-benzyl-1-(benzyloxymethyl)-5-isopropyluracil 6-cyclohexylsulfanyl-1-ethoxymethyl-5-isopropyluracil 6-methyl-5-[(1E)-3-oxobut-1-en-1-yl]uracil 6-methyluracil 6-propyl-2-thiouracil aminouracil butafenacil dasabuvir emivirine orotate orotic acid saflufenacil thiouracil tipiracil uracil-5-carboxylic acid uracil-6-ylacetic acid uridine uridines Show first 5 Terms
inverse is_substituent_group_from: uracil-1-yl group

uracil-1-yl group Show first 5 Terms
inverse is_tautomer_of: (4S)-4-hydroxy-3,4-dihydropyrimidin-2(1H)-one

(4S)-4-hydroxy-3,4-dihydropyrimidin-2(1H)-one Show first 5 Terms
is_tautomer_of: (4S)-4-hydroxy-3,4-dihydropyrimidin-2(1H)-one

(4S)-4-hydroxy-3,4-dihydropyrimidin-2(1H)-one Show first 5 Terms

Phenotype

Phenotype resulting from uracil

Phenotype where environments contain uracil

Phenotype modified by environments containing uracil

Human Disease Model