Search Ontology:
ChEBI

RSL3

Term ID
CHEBI:173109
Synonyms
  • (1S,3R)-RSL3
  • methyl (1S,3R)-2-(chloroacetyl)-1-[4-(methoxycarbonyl)phenyl]-2,3,4,4a,9,9a-hexahydro-1H-beta-carboline-3-carboxylate
  • ras-selective lethal small molecule 3
Definition
A beta-carboline that is 2,3,4,4a,9,9a-hexahydro-1H-beta-carboline in which the hydrogens at positions 1, 2 and 3 are replaced by 4-(methoxycarbonyl)phenyl, chloroacetyl and methoxycarbonyl groups, respectively (the 1S,2R stereoisomer). It is a potential antineoplastic agent which triggers ferroptosis by inactivating the glutathione peroxidase 4 (GPX4) enzyme.
References
(all 31)
Ontology
ChEBI  ( EBI )
Relationships
Phenotype
Phenotype resulting from RSL3
Phenotype where environments contain RSL3
Phenotype modified by environments containing RSL3
Phenotype affecting RSL3
Human Disease Model
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