ferrostatin-1

Term ID

CHEBI:173086

Synonyms

3-amino-4-cyclohexylaminobenzoic acid ethyl ester
ethyl 3-amino-4-(cyclohexylamino)benzoate
Fer-1
ferrrostatin 1

Definition

An ethyl ester resulting from the formal condensation of the carboxy group of 3-amino-4-(cyclohexylamino)benzoic acid with ethanol. It is a potent inhibitor of ferroptosis, a distinct non-apoptotic form of cell death caused by lipid peroxidation. It is also a radical-trapping antioxidant and has the ability to reduce the accumulation of lipid peroxides and chain-carrying peroxyl radicals.

References

cas:347174-05-4
pubmed:22632970
pubmed:26385697
pubmed:26410073
pubmed:26696014
pubmed:28250973
pubmed:28386601
pubmed:28783875
pubmed:30354101
pubmed:31531196
pubmed:31571665
pubmed:31574461
pubmed:31864943
pubmed:32161620
pubmed:32984038
pubmed:33109343
pubmed:33126055
pubmed:33278745
pubmed:33464146
pubmed:33631670
pubmed:33669598
pubmed:33991524

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from ferrostatin-1

Phenotype where environments contain ferrostatin-1

Phenotype modified by environments containing ferrostatin-1

Phenotype affecting ferrostatin-1

Human Disease Model