bictegravir

Term ID

CHEBI:172943

Synonyms

(2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
bictegravir
bictegravirum
GS-9883
GS-9883-01

Definition

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2R,5S,13aR)-8-hydroxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxylic acid with the amino group of 2,4,6-trifluorobenzylamine. It is a second-generation integrase strand transfer inhibitor (INSTI) and used (as its sodium salt) for the treatment of HIV-1.

References

cas:1611493-60-7
chemspider:44208822
drugbank:DB11799
kegg.drug:D10909
pdb-ccd:KLQ
pmc:PMC7776652
pmc:PMC7777652
pubmed:27645238
pubmed:28196003
pubmed:29746268
pubmed:31840682
pubmed:32001521
pubmed:32001525
pubmed:32041480
pubmed:32623580
pubmed:32668455
pubmed:32693738
pubmed:32796211
pubmed:32862660
pubmed:32868324
pubmed:32945851
pubmed:33105171
pubmed:33202006
pubmed:33280486
pubmed:33390993
pubmed:33511239
pubmed:33521960
pubmed:33526487
pubmed:33626178
pubmed:33649107
pubmed:33686573
pubmed:33729482
pubmed:33880558
pubmed:33977505
wikipedia.en:Bictegravir

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from bictegravir

Phenotype where environments contain bictegravir

Phenotype modified by environments containing bictegravir

Phenotype affecting bictegravir

Human Disease Model