nirmatrelvir

Term ID

CHEBI:170007

Synonyms

(1R,2S,5S)-N-{(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide
nirmatrelvir
nirmatrelvirum
PF 07321332
PF-07321332
PF07321332

Definition

An azabicyclohexane that is (1R,5S)-3-azabicyclo[3.1.0]hexane substituted by {(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl}aminoacyl, 3-methyl-N-(trifluoroacetyl)-L-valinamide, methyl and methyl groups at positions 2S, 3, 6 and 6, respectively. It is the first orally administered inhibitor of SARS-CoV-2 main protease developed by Pfizer and used in combination with ritonavir for the treatment of COVID-19.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: azabicyclohexane nitrile organofluorine compound pyrrolidin-2-ones pyrrolidinecarboxamide ... Show All 7 Terms

azabicyclohexane nitrile organofluorine compound pyrrolidin-2-ones pyrrolidinecarboxamide secondary carboxamide tertiary carboxamide Show first 5 Terms
has_role: anticoronaviral agent EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor

anticoronaviral agent EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor Show first 5 Terms
inverse has_part: Paxlovid

Paxlovid Show first 5 Terms

Phenotype

Phenotype resulting from nirmatrelvir

Phenotype where environments contain nirmatrelvir

Phenotype modified by environments containing nirmatrelvir

Human Disease / Model Data

Citations