mycophenolic acid

Term ID

CHEBI:168396

Synonyms

• (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid
• (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid
• acide mycophenolique
• acido micofenolico
• acidum mycophenolicum
• Micofenolico acido
• Mycophenolate
• mycophenolic acid
• Mycophenolsaeure

Definition

A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.

References

• cas:24280-93-1
• drugbank:DB01024
• drugcentral:1860
• kegg.drug:D05096
• patent:US4753935
• pdb-ccd:MOA
• pubmed:11272311
• pubmed:15470161
• pubmed:16629948
• pubmed:16640327
• pubmed:17482154
• pubmed:17498396
• pubmed:18194117
• pubmed:18611107
• pubmed:18996104
• pubmed:19689217
• reaxys:318158
• wikipedia.en:Mycophenolic_acid

Ontology

ChEBI  ( EBI )

Resources

CTD