PJ34

Term ID

CHEBI:167900

Synonyms

2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide
2-(dimethylaminoacetylamino)-5,6-dihydrophenanthridine-6-one
N(2),N(2)-dimethyl-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)glycinamide
N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)acetamide
N-(5,6-dihydro-6-oxophenanthridine-2-yl)-2-(dimethylamino)acetamide
PJ 34
PJ-34

Definition

A member of the class of phenanthridines that is 5,6-dihydrophenanthridine substituted at positions 2 and 6 by (N,N-dimethylglycyl)amino and oxo groups, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC₅₀ of 110 nM and 86 nM, respectively) and exhibits anti-cancer, cardioprotective and neuroprotective properties.

References

cas:344458-19-1
chemspider:4692
drugbank:DB08348
lincs.smallmolecule:LSM-4937
pdb-ccd:P34
pubmed:11179503
pubmed:11845877
pubmed:15458385
pubmed:16107839
pubmed:17612561
pubmed:18276581
pubmed:18575783
pubmed:18695907
pubmed:19354255
pubmed:19890834
pubmed:21190076
pubmed:21623955
pubmed:22297980
pubmed:22561282
pubmed:22995423
pubmed:23011206
pubmed:23995751
pubmed:24564608
pubmed:24900770
pubmed:25286857
pubmed:25446913
pubmed:25635049
pubmed:25934569
pubmed:26497583
pubmed:27002155
pubmed:27427773
pubmed:28001384
pubmed:28791810
pubmed:29317476
pubmed:29651748
pubmed:30139380
pubmed:30665718
pubmed:30683694
pubmed:31133874
pubmed:31276434
pubmed:31679124
pubmed:31692907
pubmed:32082490
pubmed:32478624
pubmed:32575437
pubmed:32911782
pubmed:33368686
pubmed:33484702
pubmed:33770364

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from PJ34

Phenotype where environments contain PJ34

Phenotype modified by environments containing PJ34

Phenotype affecting PJ34

Human Disease Model