brivanib

Term ID

CHEBI:167686

Synonyms

• (2R)-1-({4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)propan-2-ol
• (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol
• BMS 540215
• BMS-540215
• BMS540215

Definition

A secondary alcohol resulting from the hydrolysis of the carboxylic ester group of brivanib alaninate. It is a dual VEGFR-2/FGFR-1 kinase inhibitor whose alanine prodrug, brivanib alaninate is currently under development as an oral agent for the treatment of cancer.

References

• cas:649735-46-6
• chemspider:9409099
• drugbank:DB11958
• kegg.drug:D09589
• patent:WO2011044019
• pubmed:16570908
• pubmed:18288793
• pubmed:19396600
• pubmed:20671097
• pubmed:21289073
• pubmed:24780101
• pubmed:30595557
• pubmed:31270802
• pubmed:31522033
• pubmed:31633365

Ontology

ChEBI  ( EBI )