MI-1148

Term ID

CHEBI:167663

Synonyms

(2S)-5-carbamimidamido-2-{[(2S)-2-{[(2S)-5-carbamimidamido-2-{2-[4-(carbamimidamidomethyl)phenyl]acetamido}pentanoyl]amino}-3,3-dimethylbutanoyl]amino}-N-(4-carbamimidoylbenzyl)pentanamide
4-(guanidinomethyl)phenylacetyl-Arg-Tle-Arg-4-amidinobenzylamide
4-guanidinomethyl-Phac-Arg-Tle-Arg-4-amba
4-guanidinomethyl-phenylacteyl-Arg-Tle-Arg-4-amidinobenzylamide
MI 1148
MI1148
N(2)-{[4-(carbamimidamidomethyl)phenyl]acetyl}-L-arginyl-3-methyl-L-valyl-N-(4-carbamimidoylbenzyl)-L-argininamide
N(2)-{[4-(carbamimidamidomethyl)phenyl]acetyl}-L-arginyl-3-methyl-L-valyl-N-[(4-carbamimidoylphenyl)methyl]-L-argininamide

Definition

A tripeptide comprising of L-arginine, 3-methyl-L-valine and L-arginine joined in sequence by peptide linkages and in which the amino terminus is substituted by a [4-(carbamimidamidomethyl)phenyl]acetyl group and the carboxy terminus is substituted by a (4-carbamimidoylbenzyl)amino group. It is a highly potent inhibitor of furin endoprotease (Ki = 5.5 pM) that has anti-infectious activity.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: tripeptide

tripeptide Show first 5 Terms
has_functional_parent: L-arginine

L-arginine Show first 5 Terms
has_role: antibacterial agent antiviral agent EC 3.4.21.75 (furin) inhibitor peptidomimetic

antibacterial agent antiviral agent EC 3.4.21.75 (furin) inhibitor peptidomimetic Show first 5 Terms

Phenotype

Phenotype resulting from MI-1148

Phenotype where environments contain MI-1148

Phenotype modified by environments containing MI-1148

Human Disease Model