LY3009120

Term ID

CHEBI:167662

Synonyms

1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}urea
DP 4978
DP-4978
DP4978
LY 3009120
LY-3009120
N-(3,3-dimethylbutyl)-N'-[2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl]urea

Definition

A member of the class of pyridopyrimidines that is pyrido[2,3-d]pyrimidine substituted by methylamino, 5-{[(3,3-dimethylbutyl)carbamoyl]amino}-4-fluoro-2-methylphenyl, and methyl groups at positions 2, 6 and 7, respectively. It is a potent pan RAF inhibitor which inhibits BRAF(V600E), BRAF(WT) and CRAF(WT) (IC50 = 5.8, 9.1 and 15 nM, respectively). It also inhibits RAF homo- and heterodimers and exhibits anti-cancer properties.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: aminotoluene aromatic amine biaryl monofluorobenzenes phenylureas ... Show All 7 Terms

aminotoluene aromatic amine biaryl monofluorobenzenes phenylureas pyridopyrimidine secondary amino compound Show first 5 Terms
has_role: antineoplastic agent apoptosis inducer autophagy inducer B-Raf inhibitor necroptosis inhibitor

antineoplastic agent apoptosis inducer autophagy inducer B-Raf inhibitor necroptosis inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from LY3009120

Phenotype where environments contain LY3009120

Phenotype modified by environments containing LY3009120

Human Disease / Model Data

Citations