LY3009120

Term ID

CHEBI:167662

Synonyms

1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}urea
DP 4978
DP-4978
DP4978
LY 3009120
LY-3009120
N-(3,3-dimethylbutyl)-N'-[2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl]urea

Definition

A member of the class of pyridopyrimidines that is pyrido[2,3-d]pyrimidine substituted by methylamino, 5-{[(3,3-dimethylbutyl)carbamoyl]amino}-4-fluoro-2-methylphenyl, and methyl groups at positions 2, 6 and 7, respectively. It is a potent pan RAF inhibitor which inhibits BRAF^V600E, BRAF^WT and CRAF^WT (IC₅₀ = 5.8, 9.1 and 15 nM, respectively). It also inhibits RAF homo- and heterodimers and exhibits anti-cancer properties.

References

cas:1454682-72-4
pdb-ccd:4Z5
pubmed:25965804
pubmed:26343583
pubmed:26732095
pubmed:27422710
pubmed:27999210
pubmed:28382170
pubmed:28576749
pubmed:29059158
pubmed:29903896
pubmed:30272260
pubmed:30622172
pubmed:30944150
pubmed:31645440
pubmed:32366411
pubmed:33255818
pubmed:33565241

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from LY3009120

Phenotype where environments contain LY3009120

Phenotype modified by environments containing LY3009120

Phenotype affecting LY3009120

Human Disease Model