LY-2090314

Term ID

CHEBI:167661

Synonyms

• 3-[9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinylcarbonyl)pyrrolo[3,2,1-jk][1,4]benzodiazepin-7-yl]-4-imidazo[1,2-a]pyridin-3-yl-1H-pyrrole-2,5-dione
• 3-[9-fluoro-2-(piperidin-1-ylcarbonyl)-1,2,3,4-tetrahydro[1,4]diazepino[6,7,1-hi]indol-7-yl]-4-(imidazo[1,2-a]pyridin-3-yl)-1H-pyrrole-2,5-dione
• LY 2090314
• LY2090314

Definition

A member of the class of diazepinoindoles that is 1,2,3,4-tetrahydro[1,4]diazepino[6,7,1-hi]indole substituted by piperidin-1-ylcarbonyl, 4-(imidazo[1,2-a]pyridin-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl and fluoro groups at position 2, 7 and 9, respectively. It is a potent ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 values of 1.5 nM and 0.9 nM for GSK-3alpha and GSK-3beta. The drug is in clinical development for the treatment of advanced/metastatic cancer.

References

• CAS:603288-22-8
• Chemspider:8204956
• DrugBank:DB11913
• LINCS:LSM-45915
• PMID:15267232
• PMID:23305709
• PMID:24658455
• PMID:25915038
• PMID:26403509
• PMID:26735141
• PMID:26967552
• PMID:28397338
• PMID:28766886
• PMID:28772167
• PMID:29593255
• PMID:29751783
• PMID:31261037
• PMID:31562256
• PMID:31623866
• PMID:32382110
• PMID:32391602
• PMID:32539133

Ontology

ChEBI  ( EBI )