CP-724714

Term ID

CHEBI:167658

Synonyms

• (E)-2-methoxy-N-[3-[4-[[3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl]amino]quinazolin-6-yl]allyl]ethanamide
• 2-methoxy-N-[(2E)-3-(4-{3-methyl-4-[(6-methylpyridin-3-yl)oxy]anilino}quinazolin-6-yl)prop-2-en-1-yl]acetamide
• 2-methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]-acetamide
• 2-methoxy-N-[(E)-3-[4-[3-methyl-4-(6-methylpyridin-3-yl)oxyanilino]quinazolin-6-yl]prop-2-enyl]acetamide
• CP 724714
• CP-724,714
• CP724714

Definition

A 2-methoxy-N-[3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide in which the double bond adopts a trans-configuration. It is a potent inhibitor of HER2/ErbB2 (IC₅₀ = 10 nM) and exhibits anti-cancer activity.

References

• cas:845680-17-3
• chemspider:8050601
• drugbank:DB12302
• lincs.smallmolecule:LSM-42777
• pubmed:17285315
• pubmed:17317835
• pubmed:17805538
• pubmed:17942920
• pubmed:18500794
• pubmed:19223659
• pubmed:25426072
• pubmed:26846307
• pubmed:28014873
• pubmed:28902361
• pubmed:29662626
• pubmed:30858165
• pubmed:31613219
• pubmed:33463944

Ontology

ChEBI  ( EBI )