CHIR-98014

Term ID

CHEBI:167657

Synonyms

• 6-N-[2-[[4-(2,4-dichlorophenyl)-5-imidazol-1-ylpyrimidin-2-yl]amino]ethyl]-3-nitropyridine-2,6-diamine
• CHIR 98014
• CHIR98014
• N(6)-(2-{[4-(2,4-dichlorophenyl)-5-(1H-imidazol-1-yl)pyrimidin-2-yl]amino}ethyl)-3-nitropyridine-2,6-diamine
• N-6-[2-[[4-(2,4-dichlorophenyl)-5-(1H-imidazol-1-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-2,6-pyridinediamine

Definition

A member of the class of aminopyrimidines that is pyrimidine substituted by {2-[(6-amino-5-nitropyridin-2-yl)amino]ethyl}amino, 2,4-dichlorophenyl, and 1H-imidazol-1-yl groups at positions 2, 4 and 5, respectively. It is a potent ATP-competitive inhibitor of GSK3α and GSK3β (IC₅₀ values of 0.65 and 0.58 nM, respectively).

References

• cas:252935-94-7
• chemspider:27445282
• pubmed:12606497
• pubmed:24779365
• pubmed:26149502
• pubmed:29016121
• pubmed:29436606
• pubmed:29842899
• pubmed:30662679
• pubmed:31540917
• pubmed:32236757
• pubmed:33667649

Ontology

ChEBI  ( EBI )