brivanib alaninate

Term ID

CHEBI:167656

Synonyms

• (1R,2S)-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester
• (2R)-1-({4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)propan-2-yl (2S)-2-aminopropanoate
• (2R)-1-({4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)propan-2-yl L-alaninate
• alaninate de brivanib
• alaninati brivanibum
• alaninato de brivanib
• BMS 582664
• BMS-582664
• BMS582664
• brivanib alaninate

Definition

A carboxylic ester resulting from the formal condensation of the carboxy group of L-alanine with the hydroxy group of brivanib. It is a prodrug of brivanib (BMS-540215), a potent oral dual inhibitor of VEGFR-2 and FGFR-1 (IC50 of 25 nM and 148 nM, respectively) and was in development for the treatment of hepatocellular and colon carcinomas.

References

• CAS:649735-63-7
• Chemspider:9330033
• DrugBank:DB11865
• KEGG:D08878
• PMID:16570908
• PMID:17638901
• PMID:18288793
• PMID:18815076
• PMID:18829493
• PMID:19396600
• PMID:20024612
• PMID:20303261
• PMID:21115896
• PMID:21289073
• PMID:21391890
• PMID:21629245
• PMID:21659627
• PMID:22189636
• PMID:22983304
• PMID:23030483
• PMID:23690424
• PMID:24325631
• PMID:24780101
• PMID:25470221
• PMID:25724158
• PMID:26852852
• PMID:27771049
• PMID:30855507
• Wikipedia:Brivanib_alaninate

Ontology

ChEBI  ( EBI )