Search Ontology:
ChEBI
brivanib alaninate
- Term ID
- CHEBI:167656
- Synonyms
-
- (1R,2S)-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester
- (2R)-1-({4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)propan-2-yl (2S)-2-aminopropanoate
- (2R)-1-({4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)propan-2-yl L-alaninate
- alaninate de brivanib
- alaninati brivanibum
- alaninato de brivanib
- BMS 582664
- BMS-582664
- BMS582664
- brivanib alaninate
- Definition
- A carboxylic ester resulting from the formal condensation of the carboxy group of L-alanine with the hydroxy group of brivanib. It is a prodrug of brivanib (BMS-540215), a potent oral dual inhibitor of VEGFR-2 and FGFR-1 (IC50 of 25 nM and 148 nM, respectively) and was in development for the treatment of hepatocellular and colon carcinomas.
- References
-
- cas:649735-63-7
- chemspider:9330033
- drugbank:DB11865
- kegg.drug:D08878
- pubmed:16570908
- pubmed:17638901
- pubmed:18288793
- pubmed:18815076
- pubmed:18829493
- pubmed:19396600
- pubmed:20024612
- pubmed:20303261
- pubmed:21115896
- pubmed:21289073
- pubmed:21391890
- pubmed:21629245
- pubmed:21659627
- pubmed:22189636
- pubmed:22983304
- pubmed:23030483
- pubmed:23690424
- pubmed:24325631
- pubmed:24780101
- pubmed:25470221
- pubmed:25724158
- pubmed:26852852
- pubmed:27771049
- pubmed:30855507
- wikipedia.en:Brivanib_alaninate
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from brivanib alaninate
Phenotype where environments contain brivanib alaninate
Phenotype modified by environments containing brivanib alaninate
Phenotype affecting brivanib alaninate
Human Disease Model