Search Ontology:
ChEBI
BMS-214662
- Term ID
- CHEBI:167655
- Synonyms
-
- (3R)-3-benzyl-1-(1H-imidazol-5-ylmethyl)-4-(thiophen-2-ylsulfonyl)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile
- (3R)-3-benzyl-1-(1H-imidazol-5-ylmethyl)-4-thiophen-2-ylsulfonyl-3,5-dihydro-2H-1,4-benzodiazepine-7-carbonitrile
- (R)-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine-7-carbonitrile
- (R)-7-cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine
- BMS 214662
- BMS214662
- Definition
- A member of the class of benzodiazepines that is 2,3,4,5-tetrahydro-1H-1,4-benzodiazepine substituted by (1H-imidazol-5-yl)methyl, benzyl, (thiophen-2-yl)sulfonyl, and cyano groups at positions 1, 3R, 4 and 7, respectively. It is a potent inhibitor of farnesyltransferase (IC50 = 1.35nM) which was under clinical development for the treatment of solid tumors.
- References
-
- CAS:195987-41-8
- Chemspider:395310
- DrugBank:DB12234
- PDBeChem:BMV
- PMID:11020273
- PMID:11606387
- PMID:12789624
- PMID:15073096
- PMID:15102665
- PMID:15170324
- PMID:15356656
- PMID:15710949
- PMID:15728224
- PMID:15738311
- PMID:15756013
- PMID:15930351
- PMID:16362299
- PMID:17510207
- PMID:17956348
- PMID:18156496
- PMID:19738029
- PMID:19883257
- PMID:21483442
- PMID:23184491
- PMID:27688185
- Ontology
- ChEBI ( EBI )
- is a type of
- has_role
-
Show All 6 Terms
Show first 5 Terms
Phenotype
Phenotype resulting from BMS-214662
Phenotype where environments contain BMS-214662
Phenotype modified by environments containing BMS-214662
Human Disease / Model Data
Citations