AZD2858

Term ID

CHEBI:167652

Synonyms

• 3-amino-6-[4-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-N-3-pyridinyl-2-pyrazinecarboxamide
• 3-amino-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-N-(pyridin-3-yl)pyrazine-2-carboxamide
• AZD 2858
• AZD-2858

Definition

A member of the class of pyrazines that is pyrazine substituted by (pyridin-3-yl)aminocarbonyl, amino, and 4-(4-methylpiperazine-1-sulfonyl)phenyl groups at positions 2, 3 and 6, respectively. It is a potent inhibitor of GSK3alpha and GSK3beta (IC50 values of 0.9 and 4.9 nM, respectively) and increases bone mass (via Wnt activation) in rats.

References

• CAS:486424-20-8
• Chemspider:8314492
• PDBeChem:GR9
• PMCID:PMC4200977
• PMCID:PMC6795005
• PMID:22142634
• PMID:22489897
• PMID:23337038
• PMID:23872097
• PMID:27789709
• PMID:28881139

Ontology

ChEBI  ( EBI )