AZD2858

Term ID

CHEBI:167652

Synonyms

3-amino-6-[4-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-N-3-pyridinyl-2-pyrazinecarboxamide
3-amino-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-N-(pyridin-3-yl)pyrazine-2-carboxamide
AZD 2858
AZD-2858

Definition

A member of the class of pyrazines that is pyrazine substituted by (pyridin-3-yl)aminocarbonyl, amino, and 4-(4-methylpiperazine-1-sulfonyl)phenyl groups at positions 2, 3 and 6, respectively. It is a potent inhibitor of GSK3α and GSK3β (IC₅₀ values of 0.9 and 4.9 nM, respectively) and increases bone mass (via Wnt activation) in rats.

References

cas:486424-20-8
chemspider:8314492
pdb-ccd:GR9
pmc:PMC4200977
pmc:PMC6795005
pubmed:22142634
pubmed:22489897
pubmed:23337038
pubmed:23872097
pubmed:27789709
pubmed:28881139

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from AZD2858

Phenotype where environments contain AZD2858

Phenotype modified by environments containing AZD2858

Phenotype affecting AZD2858

Human Disease Model