ASP-3026

Term ID

CHEBI:167650

Synonyms

• 2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine
• ASP 3026
• ASP3026
• N(2)-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N(4)-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine
• N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N'-[2-(propan-2-ylsulfonyl)phenyl]-1,3,5-triazine-2,4-diamine

Definition

A member of the class of diamino-1,3,5-triazines that is 1,3,5-triazine-2,4-diamine in which the amino groups at positions 2 and 4 are respectively carrying 2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl and 2-(propan-2-ylsulfonyl)phenyl substituents. It is a potent inhibitor of anaplastic lymphoma kinase (ALK), Ack and ROS1 activity (IC₅₀ values are 3.5, 5.8 and 8.9 nM respectively) and exhibits anti-cancer properties.

References

• cas:1097917-15-1
• chemspider:28424239
• drugbank:DB12729
• pdb-ccd:F6O
• pubmed:24419060
• pubmed:25026277
• pubmed:25727400
• pubmed:25749034
• pubmed:25888090
• pubmed:26020125
• pubmed:26027465
• pubmed:26964870
• pubmed:26966027
• pubmed:27565932
• pubmed:28930717
• pubmed:29491259
• pubmed:31177400
• pubmed:31340850
• pubmed:33053158
• pubmed:33331996

Ontology

ChEBI  ( EBI )