JTE-607 dihydrochloride

Term ID

CHEBI:167629

Synonyms

• (-)-ethyl-N-[3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl]-L-phenylalaninate dihydrochloride
• ethyl (2S)-2-{3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzamido}-3-phenylpropanoate dihydrochloride
• ethyl N-{3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl}-L-phenylalaninate dihydrochloride
• JTE 607
• JTE 607 dihydrochloride
• JTE-607
• JTE-607 .2HCl
• JTE-607 dihydrochloride
• N-[3,5-dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride

Definition

The dihydrochloride salt of JTE-607. It is a cytokine inhibitor which suppresses the production of proinflammatory cytokines such as interleukin (IL-1β), IL-6, IL-8, granulocyte macrophage colony stimulating factor (GM-CSF), and tumor necrosis factor (TNF-α). It acts as a pro-drug which is cleaved by carboxylesterase 1 (CES1) to its active free acid form, which then binds to cleavage and polyadenylation specificity factor 3 (CPSF3).

References

• cas:188791-09-5
• pubmed:10493164
• pubmed:12005207
• pubmed:12388363
• pubmed:15044056
• pubmed:15173729
• pubmed:15280441
• pubmed:16982331
• pubmed:18691526
• pubmed:20028380
• pubmed:21820084
• pubmed:31399191
• pubmed:31819276

Ontology

ChEBI  ( EBI )