Search Ontology:
ChEBI

1,8-dihydroxynaphthalene-melanin

Term ID
CHEBI:167605
Synonyms
  • 1,8-DHN-melanin
  • 1,8-dihydroxynaphthalene (DHN) melanin
  • 1,8-dihydroxynaphthalene (DHN)-melanin
  • 1,8-dihydroxynaphthalene melanin
Definition
A melanin pigment produced by certain fungi. It plays important roles in UV protection, oxidative stress and pathogenesis. In Aspergillus fumigatus, it is used as a virulence factor and plays an important role in the survival of the fungus during unfavorable conditions both in vivo and in vitro, and protects it from the host immune system. The pigment is generally synthesised from the pentaketide pathway in which 1,8-dihydroxynaphthalene is the immediate precursor which is polymerized to 1,8-dihydroxynaphthalene-melanin by a laccase enzyme.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_functional_parent
has_role
Phenotype
Phenotype resulting from 1,8-dihydroxynaphthalene-melanin
Phenotype where environments contain 1,8-dihydroxynaphthalene-melanin
Phenotype modified by environments containing 1,8-dihydroxynaphthalene-melanin
Human Disease Model
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