delgocitinib

Term ID

CHEBI:167600

Synonyms

• 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile
• Corectim
• delgocitinib
• delgocitinibum
• JTE-052
• JTE-052A
• LEO 124249
• LEO 124249A
• LEO-124249
• LEO-124249A

Definition

A pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine substituted by a (3S,4R)-1-(cyanoacetyl)-3-methyl-1,6-diazaspiro[3.4]octan-6-yl group at position 4. It is a pan-Janus kinase (JAK) inhibitor and is approved for treatment of atopic dermatitis (AD) in Japan.

References

• cas:1263774-59-9
• chemspider:59718502
• drugbank:DB16133
• kegg.drug:D11046
• patent:US20140187534
• pdb-ccd:FHX
• pubmed:25387665
• pubmed:26115905
• pubmed:26546348
• pubmed:27665390
• pubmed:28423239
• pubmed:28960254
• pubmed:29665062
• pubmed:31425780
• pubmed:31466119
• pubmed:31820485
• pubmed:31924380
• pubmed:32029304
• pubmed:32166597
• pubmed:32511913
• pubmed:33334258
• pubmed:33377547
• pubmed:33605031

Ontology

ChEBI  ( EBI )