delgocitinib

Term ID

CHEBI:167600

Synonyms

• 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile
• Corectim
• delgocitinib
• delgocitinibum
• JTE-052
• JTE-052A
• LEO 124249
• LEO 124249A
• LEO-124249
• LEO-124249A

Definition

A pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine substituted by a (3S,4R)-1-(cyanoacetyl)-3-methyl-1,6-diazaspiro[3.4]octan-6-yl group at position 4. It is a pan-Janus kinase (JAK) inhibitor and is approved for treatment of atopic dermatitis (AD) in Japan.

References

• CAS:1263774-59-9
• Chemspider:59718502
• DrugBank:DB16133
• KEGG:D11046
• PDBeChem:FHX
• PMID:25387665
• PMID:26115905
• PMID:26546348
• PMID:27665390
• PMID:28423239
• PMID:28960254
• PMID:29665062
• PMID:31425780
• PMID:31466119
• PMID:31820485
• PMID:31924380
• PMID:32029304
• PMID:32166597
• PMID:32511913
• PMID:33334258
• PMID:33377547
• PMID:33605031
• Patent:US20140187534

Ontology

ChEBI  ( EBI )