monomethyl fumarate

Term ID

CHEBI:167450

Synonyms

(2E)-4-methoxy-4-oxobut-2-enoic acid
(E)-4-methoxy-4-oxobut-2-enoic acid
Bafiertam
fumarate de monomethyle
fumarato de monometilo
fumaric acid monomethyl ester
methyl hydrogen fumarate
mono-methyl fumarate
monomethyl fumarate
monomethylfumarate
monomethylis fumaras

Definition

A dicarboxylic acid monoester resulting from the formal condensation of one of the carboxy groups of fumaric acid with methanol. Is is a metabolite of dimethyl fumarate and used for the the treatment of patients with relapsing multiple sclerosis (MS). It also induces the NFE2L2 (Nrf2) transcription factor by binding to KEAP1.

References

cas:2756-87-8
chemspider:4520322
drugbank:DB14219
foodb.food:FDB011972
hmdb:HMDB0033809
kegg.drug:D11492
pubmed:16187092
pubmed:18722346
pubmed:25793262
pubmed:26679389
pubmed:26689280
pubmed:27393735
pubmed:27614618
pubmed:27807435
pubmed:28181536
pubmed:28284222
pubmed:28832396
pubmed:28873360
pubmed:29106333
pubmed:30412724
pubmed:30880045
pubmed:30924852
pubmed:31210338
pubmed:31344443
pubmed:31362266
pubmed:31387164
pubmed:31832203
pubmed:32047722
pubmed:32150247
pubmed:32426288
pubmed:32629403
pubmed:32771469
pubmed:33091427
pubmed:33191652
pubmed:33435037
reaxys:1722673
wikipedia.en:Monomethyl_fumarate

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from monomethyl fumarate

Phenotype where environments contain monomethyl fumarate

Phenotype modified by environments containing monomethyl fumarate

Phenotype affecting monomethyl fumarate

Human Disease Model