dextromethadone

Term ID

CHEBI:167308

Synonyms

• (+)-(S)-6-(dimethylamino)-4,4-diphenyl-3-heptanone
• (+)-methadone
• (6S)-6-(dimethylamino)-4,4-diphenylheptan-3-one
• (6S)-methadone
• (S)-(+)-methadone
• (S)-6-(dimethylamino)-4,4-diphenyl-3-heptanone
• (S)-methadone
• d-6-(dimethylamino)-4,4-diphenyl-3-heptanone
• d-methadone
• REL-1017
• S-(+)-methadone
• S-methadone

Definition

A 6-(dimethylamino)-4,4-diphenylheptan-3-one that has (S)-configuration. It is the less active enantiomer of methadone and has very little activity on opioid receptors and mainly responsible for the inhibition of hERG K+ channels and thus for cardiac toxicity. The drug is currently under clinical development for the treatment of major depressive disorder.

References

• cas:5653-80-5
• chemspider:559067
• drugbank:DB15198
• pubmed:21175445
• pubmed:23249875
• pubmed:23935979
• pubmed:27055456
• pubmed:27456067
• pubmed:27974484
• pubmed:29458047
• pubmed:30907440
• pubmed:31091116
• pubmed:31368772
• pubmed:31454827
• pubmed:32302325
• pubmed:33345336
• reaxys:3213667
• wikipedia.en:Dextromethadone

Ontology

ChEBI  ( EBI )