triclosan

Term ID

CHEBI:164200

Synonyms

2,4,4'-Trichloro-2'-hydroxydiphenyl ether
5-Chloro-2-(2,4-dichloro-phenoxy)-phenol
5-chloro-2-(2,4-dichlorophenoxy)phenol
Triclosan
triclosanum

(all 5)

Definition

An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes.

References

(all 66)

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: aromatic ether dichlorobenzene monochlorobenzenes phenols

aromatic ether dichlorobenzene monochlorobenzenes phenols Show first 5 Terms
has_role: antibacterial agent antimalarial drug allergen EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor EC 1.5.1.3 (dihydrofolate reductase) inhibitor ... Show All 8 Terms

antibacterial agent antimalarial drug allergen EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor EC 1.5.1.3 (dihydrofolate reductase) inhibitor fungicide persistent organic pollutant xenobiotic Show first 5 Terms

Phenotype

Phenotype resulting from triclosan

Fish	Conditions	Phenotype	Term	Figures
AB	chemical treatment by environment: triclosan	gut il6 expression decreased amount, abnormal gut rela expression increased amount, abnormal gut casp7 expression increased amount, abnormal female organism viability, abnormal gut ighd expression decreased amount, abnormal gut ikbkb expression increased amount, abnormal gut epithelium increased thickness, abnormal intestinal epithelium malformed, abnormal enterocyte vacuolated, abnormal gut ikbkg expression increased amount, abnormal gut tlr4ba expression increased amount, abnormal gut host-mediated regulation of intestinal microbiota composition decreased process quality, abnormal gut gadd45ba expression increased amount, abnormal gut baxb expression increased amount, abnormal gut myd88 expression increased amount, abnormal gut baxa expression increased amount, abnormal gut casp3a expression increased amount, abnormal male organism viability, abnormal gut casp3b expression increased amount, abnormal gut il1b expression decreased amount, abnormal gut non-canonical NF-kappaB signal transduction increased magnitude, abnormal gut irak4 expression increased amount, abnormal gut ighm expression decreased amount, abnormal feeding behavior decreased process quality, abnormal gut il10 expression decreased amount, abnormal	triclosan	6 figures from Liu et al., 2024

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Phenotype where environments contain triclosan

Fish	Conditions	Phenotype	Term	Figures
AB	chemical treatment by environment: triclosan	gut il6 expression decreased amount, abnormal gut rela expression increased amount, abnormal gut casp7 expression increased amount, abnormal female organism viability, abnormal gut ighd expression decreased amount, abnormal gut ikbkb expression increased amount, abnormal gut epithelium increased thickness, abnormal intestinal epithelium malformed, abnormal enterocyte vacuolated, abnormal gut ikbkg expression increased amount, abnormal gut tlr4ba expression increased amount, abnormal gut host-mediated regulation of intestinal microbiota composition decreased process quality, abnormal gut gadd45ba expression increased amount, abnormal gut baxb expression increased amount, abnormal gut myd88 expression increased amount, abnormal gut baxa expression increased amount, abnormal gut casp3a expression increased amount, abnormal male organism viability, abnormal gut casp3b expression increased amount, abnormal gut il1b expression decreased amount, abnormal gut non-canonical NF-kappaB signal transduction increased magnitude, abnormal gut irak4 expression increased amount, abnormal gut ighm expression decreased amount, abnormal feeding behavior decreased process quality, abnormal gut il10 expression decreased amount, abnormal	triclosan	6 figures from Liu et al., 2024

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Phenotype modified by environments containing triclosan

No data available

Phenotype affecting triclosan

No data available

Human Disease Model

No data available