aztreonam

Term ID

CHEBI:161680

Synonyms

• (2S,3S)-3-{(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[(2-carboxypropan-2-yloxy)imino]acetamido}-2-methyl-4-oxoazetidine-1-sulfonate
• (Z,)-2-((((2-Amino-4-thiazolyl)(((2S,3S,)-2-methyl-4-oxo-1-sulfo-3-azetidinyl)carbamoyl)methylene)amino)oxy)-2-methylpropionic acid
• Azactam
• aztreonam
• aztreonamum
• Primbactam

Definition

A synthetic monocyclic β-lactam antibiotic (monobactam), used primarily to treat infections caused by Gram-negative bacteria. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking.

References

• beilstein:3577211
• cas:78110-38-0
• drugbank:DB00355
• drugcentral:279
• kegg.compound:C06840
• kegg.drug:D00240
• patent:NL8100571
• pdb-ccd:AZR
• pubmed:1384868
• pubmed:15123864
• pubmed:24119095
• pubmed:24176390
• pubmed:24369293
• pubmed:25049240
• pubmed:25091537
• pubmed:25295210
• pubmed:28543395
• pubmed:29017833
• reaxys:3577211
• wikipedia.en:Aztreonam

Ontology

ChEBI  ( EBI )

Resources

CTD