N(7)-methyl-GpppA

Term ID

CHEBI:157762

Synonyms

• 2-amino-9-[(2R,3R,4S,5R)-5-({[(R)-{[(R)-{[(S)-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-3,4-dihydroxytetrahydrofuran-2-yl]-7-methyl-6
• 2-amino-9-[(2R,3R,4S,5R)-5-({[{[{[{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-3,4-dihydroxytetrahydrofuran-2-yl]-7-methyl-6-oxo-6,9-dih
• 7-methyl-GpppA
• [(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-7-ium-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl [[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl] hydrogen phosphate
• m(7)-GpppA
• m(7)GP3A
• m(7)GpppA
• N(7)-MeGpppA
• P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate

Definition

A guanosine 5'-phosphate that is 7-methyl-GTP(1+) in which the hydroxy group of the terminal phosphate is substituted by an adenosyl group. It is a cap analog that can be incorporated into mRNA.

References

• chemspider:393721
• drugbank:DB01649
• pdb-ccd:GTA
• pubmed:11879179
• pubmed:12691746
• pubmed:15068804
• pubmed:15590684
• pubmed:16271312
• pubmed:17686489
• pubmed:18501946
• pubmed:18976670
• pubmed:19101564
• pubmed:19307714
• pubmed:19710013
• pubmed:20655081
• pubmed:28254839
• pubmed:33972410
• pubmed:35758665

Ontology

ChEBI  ( EBI )