holomycin

Term ID

CHEBI:156451

Synonyms

• 6-(acetylamino)-1,2-dithiolo[4,3-b]pyrrol-5(4H)-one
• 6-acetamido-1,2-dithiolo[4,3-b]pyrrol-5(4H)-one
• N-(4,5-dihydro-5-oxo-1,2-dithiolo-[4,3-b]pyrrol-6-yl)acetamide
• N-(5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl)acetamide
• N-(5-oxo-4H-dithiolo[4,3-b]pyrrol-6-yl)acetamide
• N-demethylthiolutin
• N-{5-oxo-4H,5H-[1,2]dithiolo[4,3-b]pyrrol-6-yl}acetamide

Definition

A dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 5 and 6 have been replaced by oxo and acetamido groups, respectively. It is an inhibitor of DNA-dependent RNA polymerase, and exhibits antibacterial and antitumour properties.

References

• cas:488-04-0
• metacyc.compound:CPD-17940
• pubmed:11158751
• pubmed:12426344
• pubmed:16890414
• pubmed:17606690
• pubmed:21041678
• pubmed:21339958
• pubmed:21342467
• pubmed:21504228
• pubmed:22344669
• pubmed:23097183
• pubmed:23147422
• pubmed:23572522
• pubmed:24141227
• pubmed:24323287
• pubmed:27018252
• pubmed:28209778
• pubmed:28627048
• pubmed:28740758
• pubmed:30194098
• pubmed:32642829
• pubmed:468729
• pubmed:863793
• pubmed:894386
• reaxys:188430

Ontology

ChEBI  ( EBI )

Resources

CTD