holomycin

Term ID

CHEBI:156451

Synonyms

6-(acetylamino)-1,2-dithiolo[4,3-b]pyrrol-5(4H)-one
6-acetamido-1,2-dithiolo[4,3-b]pyrrol-5(4H)-one
N-(4,5-dihydro-5-oxo-1,2-dithiolo-[4,3-b]pyrrol-6-yl)acetamide
N-(5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl)acetamide
N-(5-oxo-4H-dithiolo[4,3-b]pyrrol-6-yl)acetamide
N-demethylthiolutin
N-{5-oxo-4H,5H-[1,2]dithiolo[4,3-b]pyrrol-6-yl}acetamide

(all 7)

Definition

A dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 5 and 6 have been replaced by oxo and acetamido groups, respectively. It is an inhibitor of DNA-dependent RNA polymerase, and exhibits antibacterial and antitumour properties.

References

(all 26)

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: acetamides dithiolopyrrolone antibiotic

acetamides dithiolopyrrolone antibiotic Show first 5 Terms
has_role: antibacterial agent antineoplastic agent bacterial metabolite chelator EC 2.7.7.6 (RNA polymerase) inhibitor ... Show All 6 Terms

antibacterial agent antineoplastic agent bacterial metabolite chelator EC 2.7.7.6 (RNA polymerase) inhibitor marine metabolite Show first 5 Terms
inverse has_functional_parent: thiolutin

thiolutin Show first 5 Terms

Phenotype

Phenotype resulting from holomycin

Phenotype where environments contain holomycin

Phenotype modified by environments containing holomycin

Phenotype affecting holomycin

Human Disease Model